Inflammation, Oxidation and Venous Neointimal Hyperplasia Precede Vascular Injury from AVF Creation in CKD Patients
نویسندگان
چکیده
منابع مشابه
Gliotoxin inhibits neointimal hyperplasia after vascular injury in rats.
Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migration and proliferation of cultured rat VSMC and neointimal formation in injur...
متن کاملSevere Endothelial Damage in Chronic Kidney Disease Patients Prior to Haemodialysis Vascular Access Surgery.
BACKGROUND Hemodialysis as an efficient therapy for advanced CKD is the most used treatment modality all over the world. Even though primary AVF is widely accepted as a best permanent vascular access in hemodialysis patients, up to 60% of all fistulas fail to mature. The pathogenesis of early fistula failure is not very well understood. Many general and local factors are involved: patient's age...
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Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملPrediction of arteriovenous fistula stenosis and failure via in vivo inflammation and fibrin molecular imaging
Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملEndothelial-like cells differentiated from mesenchymal stem cells attenuate neointimal hyperplasia after vascular injury
The present study investigated the contribution of bone marrow-derived mesenchymal stem cells (BM‑MSCs) to neointimal formation, and whether endothelial‑like cells (ELCs) differentiated from BM‑MSCs could attenuate intimal hyperplasia following vascular injury. BM‑MSCs were isolated from rat femurs and tibias and expanded ex vivo. Differentiation into ELCs was induced by cultivation in the pres...
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ژورنال
عنوان ژورنال: The Journal of Vascular Access
سال: 2011
ISSN: 1129-7298,1724-6032
DOI: 10.5301/jva.5000024